IndraLab

Statements


CYLD activates RHOA. 5 / 6
| 5

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"In agreement with the CYLD shRNA result, overexpression of GFP-CYLD promoted RhoA activity (XREF_FIG)."

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"These findings prompted us to investigate whether CYLD modulates other Rho family members."

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"We thus studied whether CYLD promoted RhoA activity by interacting with LARG."

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"We then investigated whether CYLD promoted RhoA activity via an interaction between these two proteins."

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"These results indicate that CYLD stimulates RhoA activity in a deubiquitinase activity dependent manner."