IndraLab

Statements

STAMBP binds FH. 5 / 5
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"FH-STAMBP but not FH-STAMBP (D348A) may cleave polyubiquitination chain from EGFR ( xref D)."
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"We transiently transfected the control and FH-STAMBP (D348A) constructs into H1299 cells to assess EGFR protein stability upon CHX treatment."
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"The results showed that EGFR stability did not change when FH-STAMBP (D348A) was overexpressed in these cells ( xref G), suggesting catalytic activity of STAMBP is crucial in maintaining EGFR protein stability."
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"The results demonstrated that overexpression of FH-STAMBP decreased EGFR polyubiquitination ( xref B) whereas STAMBP knockdown promoted EGFR polyubiquitination upon EGF treatment ( xref C)."
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"We also performed in vitro deubiquitination assay by incubating EGFR complex with purified FH-STAMBP or FH-STAMBP (D348A) in a deubiquitination reaction."
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