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ZUP1 increases the amount of SIRT2. 7 / 7
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"We firstly found that DUb upregulated the SIRT2 expression in LoVo cells, but DUb did not affect SIRT2 expression after SIRT2 was silenced (Figure 6A)."
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"We also found that DUb upregulated SIRT2 expression in DUb-treated HCT116 and LoVo cells and CRC tissues treated with DUb."
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"*p < 0.05; **p < 0.01; ***p < 0.001.FIGURE 5: DUb increases the expression of SIRT2."
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"DUb significantly induced mRNA expression of SIRT2 in HCT116 (B) and LoVo cells (C)."
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"(F) The results of western blotting showed that DUb markedly increased the protein expression of SIRT2 in the CT26 xenograft tumors and patient-derived xenograft (PDX) tumors (n = 3)."
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"(G) The results of immunohistochemical staining showed that DUb markedly increased the protein expression of SIRT2 in the CT26 xenograft tumors and patient-derived xenograft (PDX) tumors (n = 3)."
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"Furthermore, the results of IHC staining against SIRT2 antibodies shows that SIRT2 expression in the DUb-treated xenograft tumor is significantly increased as compared with control.Given that DUb upregulated SIRT2 expression, we speculated that DUb inhibited CRC growth by upregulating SIRT2."
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