IndraLab

Statements

Modified USP28 increases the amount of MYC. 4 / 4
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"Overexpression of USP28 in BR cells enhances c-Myc expression and hence increases ASS1 transcription upon arginine deprivation, and consequently leads to cell survival."
26771234
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"As shown in XREF_FIG, overexpression of USP28 in A549 prevented the loss of c-Myc, suggesting that USP28 was involved in c-Myc degradation."
20046830
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"Intriguingly, both ectopic expression of Usp28 in wild-type MEFs (+/+ +) and complete knockout of Usp28 (-/-) strongly and equivalently increased levels of Myc, Jun, and Notch."
25437563
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"As expected, depletion of USP28 remarkably decreased MYC protein and reversed epinephrine induced increase in MYC protein expression (XREF_SUPPLEMENTARY and XREF_FIG), whereas overexpression of USP28 enhanced MYC expression (XREF_SUPPLEMENTARY)."
30688660