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USP3 deubiquitinates CLSPN. 4 / 4
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"Moreover, we found that Smo reduced <span class="match term1">Claspin</span> polyubiquitination and proteasomal degradation by promoting <span class="match term0">USP3</span> transcription"
31900278
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"USP3 mediates the deubiquitination of claspin and leads to the successive activation of claspin-dependent ATR–CHK1 signaling, thus enhancing the radiation resistance of glioblastoma (GBM) significantl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35760282
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"Notably, this study finds that this effect is dependent on Claspin polyubiquitination and proteasomal degradation, which can be reduced by USP3 transcription, resulting in regulation of ATR-Chk1 signaling [18]."
38773075
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"Tu et al. reported that USP3 deubiquitinates Claspin, thus activating ATR-Chk1 signaling in tumor resistance to radiation23."
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