IndraLab

Statements

ATXN3 inhibits ATXN3. 4 / 9
| 4
reach
"In contrast to the findings of XREF_BIBR, polyQ expanded ataxin-3 was found to impair histone acetyltransferase activity in SCA3 mice, resulting in histone hypoacetylation."
32765211
reach
"However, whether ATXN3 loss-of-function contributes to SCA3 transcriptional dysfunction is still unknown."
30231063
reach
"The specific mechanism through which calpain inhibitor treatments increase autophagic activity in our transgenic zebrafish model of SCA3 is yet to be fully elucidated.These findings indicate that treatment with BLD-2736 may produce beneficial effects in SCA3 zebrafish via either decreasing cleavage of the ataxin-3 protein and/or increased autophagic clearance of any neurotoxic ataxin-3 protein aggregates."
| PMC
reach
"Phosphorylations of ATX3 by protein casein kinase 2 (CK2) stimulate SCA3 pathogenesis by altering its stability, nuclear localization, and inclusion formation [50,51], while GSK3β-mediated phosphorylation inhibits ATX3 aggregation which has a protective role in SCA3 pathophysiology [94]."
32512887