IndraLab

Statements

ATXN3 inhibits ATXN3. 9 / 14
| 9
reach
"Phosphorylations of ATX3 by protein casein kinase 2 (CK2) stimulate SCA3 pathogenesis by altering its stability, nuclear localization, and inclusion formation [50,51], while GSK3β-mediated phosphorylation inhibits ATX3 aggregation which has a protective role in SCA3 pathophysiology [94]."
32512887
reach
"However, whether ATXN3 loss-of-function contributes to SCA3 transcriptional dysfunction is still unknown."
30231063
reach
"Treatment with SB increased the activity of the autophagy protein quality control pathway in the SCA3 cells, decreased the presence of ataxin-3 aggregates and presence of high molecular weight ataxin-3 in an autophagy-dependent manner."
38258931
reach
"qRT‐PCR analysis shows that the expression level of SCA3 decreases to ≈5% of the wild type level in 4‐day‐old sca3‐2 mutant plants (Figure S2B, Supporting Information), while reduced to ≈15% in 10‐day‐old sca3‐2 mutant plants (Figure S2C, Supporting Information)."
39630097
reach
"In contrast to the findings of XREF_BIBR, polyQ expanded ataxin-3 was found to impair histone acetyltransferase activity in SCA3 mice, resulting in histone hypoacetylation."
32765211
reach
"The specific mechanism through which calpain inhibitor treatments increase autophagic activity in our transgenic zebrafish model of SCA3 is yet to be fully elucidated.These findings indicate that treatment with BLD-2736 may produce beneficial effects in SCA3 zebrafish via either decreasing cleavage of the ataxin-3 protein and/or increased autophagic clearance of any neurotoxic ataxin-3 protein aggregates."
| PMC
reach
"Treatment of MJD patient-derived iCNs with ALLN or calpeptin after excitotoxic L-glutamate stimulation reduced polyQ-expanded Atx3, while caspase-specific inhibitors failed to do so (Koch et al., 2011)."
36385755
reach
"Interestingly, while in SBMA, DNA damage is an outcome of toxic gain-of-function of AR, the loss-of-function of SCA3 causing protein Ataxin-3 results in perturbed Chk-1 stability and function, and hen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38492921
reach
"siRNAs complementary to ATXN3 injected in the DCN of SCA3 transgenic mice reached the target and downregulated ATXN3, preventing its aggregation [189,190]."
38391932