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Cisplatin inhibits NFKBIA. 7 / 7
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"We found that fucoxanthin pretreatment attenuated cisplatin-induced DNA-binding activity of NFκB, restored cisplatin-inhibited IκB-α - phosphorylation, and increased the ratio of Bax/Bcl-2 mRNA expression, rendering cancer cells sensitive to apoptosis induced by cisplatin."
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"As shown in Figs. 5 and 6, neither doxorubicin- nor cisplatin induced marked IkappaBalpha degradation or accumulation of nuclear NF-kappaB."
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"This conclusion was supported by the following observations : cisplatin induced IkappaBalpha degradation and NF-kappaB-dependent transcriptional activation prior to cell death; pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB activation, prevented apoptosis; lactacystin, an inhibitor of IkappaBalpha degradation, also prevented apoptosis; and finally, the expression of a super repressor mutant IkappaBalpha blocked apoptosis."
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"It was also shown that RA inhibits cisplatin induced IkappaBalpha degradation (XREF_FIG)."
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"Recently, Kim et al. reported that cisplatin induces IkappaBalpha degradation, leading to the NF-kappaB-dependent up-regulation of TNF-alpha in HNSCC cells."
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"In addition, fucoxanthin significantly and concentration-dependently restored cisplatin-inhibited IκB-α - phosphorylation in HepG2 cells at 24 h of incubation, as compared with cisplatin treatment alone ( xref D)."
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"Liu et al. [ xref ] showed that fucoxanthin pretreatment attenuated the cisplatin-induced DNA-binding activity of NF-κB, restored cisplatin-inhibited IκB-α - phosphorylation, and increased the ratio of Bax/Bcl-2 mRNA expression rendering cancer cells sensitive to apoptosis induced by cisplatin, which suggested that fucoxanthin may be an NF-κB inhibitor."
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