IndraLab

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GZ17-6.02 increases the amount of BAP1. 3 / 3
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"As a single agent, GZ17-6.02 significantly enhanced BAP1 expression (Table 6)."
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"We found that GZ17-6.02 as a single agent increased BAP1 expression in uveal melanoma cells that was not altered by ERBB receptor inhibitors."
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"Hence, our discovery that GZ17-6.02 is enhancing BAP1 expression favors increased expression from the wild type unmutated BAP1 allele in uveal melanoma cells.GZ17-6.02 changed the methylation and acetylation of Histone H3 in uveal melanoma cells, most notably, the mono-methylation of lysine 9 and lysine 4 was reduced and this correlated with a trend for increased di-methylation of lysine 4."
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