IndraLab

Statements


USP15 deubiquitinates perilipins. 2 / 2
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reach
"It is also strongly supposed that FABPs and perilipins are deubiquitinated by USP15 and that their enhanced stability synergistically contributes to increased lipid accumulation and inflammation in the development of NAFLD/NASH.An FPC diet is used to induce features of metabolic and hepatic NASH characteristics."

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"To further confirm the deubiquitination of FABPs and perilipins mediated by USP15, we used TUBE-agarose beads (tandem ubiquitin-binding entities) to identify and isolate total ubiquitinated proteins."