IndraLab

Statements


TGFB increases the amount of USP26. 5 / 5
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"Further experimentation will be required to elucidate the precise mechanism of how TGF-beta enhances USP26 expression."

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"In all cell lines tested, TGF-beta enhanced the mRNA expression levels of both USP26 and SMAD7."

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"We demonstrate that TGF-beta rapidly enhances the expression of USP26 and reinforces SMAD7 stability by limiting the ubiquitin mediated turnover of SMAD7."

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"TGFbeta enhances the expression of USP26 and reinforces SMAD7 stability by limiting the ubiquitin mediated turnover of SMAD7."

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"Our data suggest that as part of a negative feedback loop, TGF-beta enhances the expression of not only SMAD7 but also USP26, which acts to deubiquitinate and stabilize SMAD7."