IndraLab

Statements

ThiO inhibits KCNH2. 3 / 3
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"Importantly, we found that THIO increased surface hERG degradation (XREF_FIG), which indicates that THIO may increase lysosome mediated mature hERG degradation."
32064022
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"These results indicate that THIO inhibited the hERG current without altering the kinetics of channel gating, suggesting that THIO mediated hERG channel damage is dependent on a decrease in protein levels."
32064022
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"Whilst THIO produced a substantial inhibition of WT-hERG, it produced virtually no inhibition of the F656A hERG mutant."
17056009