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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Phosphorylated STAT3 increases the amount of MMP9. 2 / 2

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"HES1 was reported to enhance the phosphorylation of signal transducers and activators of transcription-3 (STAT3) by binding to STAT3 directly, and phosphorylated STAT3 can elevate MMP2 and MMP9 expression by directly binding to their promoters XREF_BIBR - XREF_BIBR."

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"During efficacy testing of hydrazinocurcumin (HC), a synthetic curcumin analogue, inhibition of STAT3 phosphorylation in BC cell lines (MDA-MB-231, MCF-7) decreased the expression of c-Myc, Bcl-xL, Bcl-2, Mcl-1, cyclin D1/D2, VEGF, MMP-2, and MMP-9 among others."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...