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Phosphorylated STAT3 increases the amount of MMP9. 4 / 4
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"In addition, the secretion of MMP9 by MNC-QQc cells is mediated by the phosphorylation of the STAT-3 pathway.The current study also identified that MNC-QQc cells increased the release of chemokine and MMP9 (Fig. 1d)."
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"During efficacy testing of hydrazinocurcumin (HC), a synthetic curcumin analogue, inhibition of STAT3 phosphorylation in BC cell lines (MDA-MB-231, MCF-7) decreased the expression of c-Myc, Bcl-xL, Bcl-2, Mcl-1, cyclin D1/D2, VEGF, MMP-2, and MMP-9 among others."
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"HES1 was reported to enhance the phosphorylation of signal transducers and activators of transcription-3 (STAT3) by binding to STAT3 directly, and phosphorylated STAT3 can elevate MMP2 and MMP9 expression by directly binding to their promoters XREF_BIBR - XREF_BIBR."
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"Moreover, 27-HC induced EMT by decreasing the expression of E-cadherin and β-catenin [ 106 ], as well as by increasing the phosphorylation of STAT3, which promoted MMP9 expression [ 107 ]."
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