IndraLab
Statements
USP2 activates Hyperglycemia. 2 / 2
|
2
reach
"USP22 in pancreatic beta-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and USP2 in hypothalamus improve hyperglycemia, whereas USP19 in adipocytes, USP21 in myocytes, and USP2, 14, and 20 in hepatocytes promote hyperglycemia."
reach
"Given that HSD1 converts circulating inactive cortisone to active cortisol [107], hepatic USP2 causes hyperglycemia by activating glucocorticoid signaling.Sustained low-grade endoplasmic reticulum (ER) stress induced by low doses of tunicamycin (200 μg/kg) treatment for two weeks increased hepatic gluconeogenesis and resulted in hyperglycemia [103]."