IndraLab

Statements

USP8 activates E3_Ub_ligase. 4 / 4
| 4
reach
"Furthermore, UBPY-dependent deubiquitination has also been suggested to prevent degradation of the E3 ligase neuregulin receptor degradation pathway protein 1 (Nrdp1), which has a role in regulating s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16996268
reach
"Ubiquitin-specific protease 8 (USP8) belongs to ubiquitin proteasome system and mediates the stability of E3 ligases."
35257552
reach
"One study showed that USP8 acts downstream of PTEN to enhance the ability of the E3 ligase Itch to reduce cFLIP stability and increase tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in human glioblastoma multiforme cells [97]."
31845722
reach
"USP8 promotes the stabilization of E3 ubiquitin ligase Nrdp1 ( Wu et al., 2004 ), and Nrdp1 regulates NF-κB and type I IFNs by targeting MYD88 and TBK1 ( Wang et al., 2009 )."
33278678