IndraLab

Statements

YOD1 inhibits RIPK2. 3 / 3
| 3
reach
"Consistently, YOD1 overexpression increased RIPK2 protein abundance and delayed RIPK2 degradation upon CHX treatment (Appendix Fig. S12B)."
39333628
reach
"In the present study, we found that NOD2-mediated protective responses in colitis were potentiated by YOD1, which inhibited the proteasomal degradation of RIPK2 by removing K48-linked polyubiquitin chains."
39333628
reach
"Indeed, we found that, after blocking protein synthesis with CHX, YOD1 deletion accelerated the degradation of RIPK2 in BMDMs in the presence or absence of L18-MDP (Fig. 5G; Appendix Fig. S12A), indicating that YOD1 increases the stability of RIPK2 protein."
39333628