IndraLab

Statements

OTUB1 activates RACK1. 7 / 7
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"Knockdown of OTUB1 accelerated the half-life reduction of RACK1 induced by CHX treatment, while MG132 treatment improved the stability of RACK1 in HCC."
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"Immunoblotting showed that OTUB1 overexpression enhanced RACK1 and led to the activation of the Akt and ERK/FAK pathways in HCC cells."
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"However, the exact mechanism of OTUB1-induced RACK1 stabilization needs to be further elucidated."
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"Although the precise mechanism by which OTUB1 induces RACK1 stabilization requires further elucidation, it is very likely that the binding between OTUB1 and RACK1 as well as OTUB1’s ability to inhibit E2-conjugating enzymes recruited by the unknown E3 ligase contribute to RACK1 stabilization induced by OTUB1."
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"OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination."
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"Our data indicated that shRNA-mediated OTUB1 knockdown reduced the quantity of RACK1 protein and that OTUB1 overexpression increased RACK1 protein in HCC cells (Fig. 4o)."
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"Therefore, OTUB1 significantly increased multiple oncogenes expression and activated PI3K/AKT and FAK/ERK signaling in a RACK1-dependent manner in HCC."
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