IndraLab

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MiR-133 decreases the amount of HCN4. 3 / 3
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"37 Relevant to the present discussion, down-regulation of miR-1 and miR-133 have been associated with increased protein levels of HCN2 and HCN4 in hypertrophic hearts, whereas transfection of miR-1 and miR-133 into angiotensin II stimulated neonatal cardiac myocytes prevented overexpression of HCN2 and HCN4."

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"The expression of cardiac pacemaker channel genes HCN2 and HCN4 is negatively regulated by miR-1 and miR-133."

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"With advancing age, the expression of miR-133 appears to decrease, simultaneously with an increase in HCN2 and HCN4 expression (Li et al., 2015), which may contribute to an increase in AF susceptibility."