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Infections increases the amount of USP18. 7 / 8
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"Here we studied the role of ISG15-specific ubiquitin-like protease 43 (USP18) in HIV-1 innate immune sensing.HIV-1 infection induces the expression of USP18 in PMA-differentiated THP-1 cells."
| PMC

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"It was found that mRNA expression levels of A3B and USP18, rather than A3A and A3G, were significantly up-regulated by the infection with Omicron BA.4/5 S protein pseudovirus (Fig. 4A and B)."

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"The above data suggest that IAV infection promotes USP18 expression in A549 cells."

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"Since infections with SA11, A5-13, Wa and KU RV strains all increased USP18 and A20 expression ( Fig. 3 A and B, Supplementary Fig. 1 ), functional significance of these genes was analyzed during RV i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"USP18 was the negative regulatory factor for IFN signaling, and DENV infection significantly increased USP18 expression (26)."

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"Ye et al. (2021) demonstrated that DENV-2 infection increased USP18 expression; USP18 overexpression enhanced DENV-2 replication, while USP18 silencing inhibited DENV-2 replication by activating the IFN-α-mediated JAK/STAT signaling pathway."

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"HIV-1 infection induces the expression of USP18 [40,41]."