IndraLab

Statements

USP22 inhibits Osteosarcoma. 4 / 4
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"Downregulation of USP22 can inhibit the glycolysis and growth of osteosarcoma cells."
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"Furthermore, ALKBH5-mediated m6A deficiency increases the expression of USP22 and RNF40 in osteosarcomas, promoting osteosarcoma cell growth and proliferation [40]."
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"Western blotting data further validated that miR-485-5p overexpression reduced the expression of USP22 protein, whereas miR-485-5p downregulation increased the USP22 protein levels in osteosarcoma cells ( Figure 5D )."
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"In addition, deficiency of ALKBH5‐mediated m6A modification in osteosarcoma causes an increase expression of histone deubiquitinase USP22 and ubiquitin ligase RNF40, which inhibits histone H2AK199 monoubiquitination, induces the expression of genes related to DNA repair, and promotes the progression of osteosarcoma."
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