IndraLab

Statements

UCHL1 activates CD36. 4 / 4
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"To further explore the molecular mechanism of UCHL1 on the regulation of CD36, we observed the inhibition of UCHL1 promotes CD36 degradation."
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"This results indicates that the suppression of lipid accumulation induced by UCHL1 inhibition or silence is a result of UCHL1 inhibition promoted CD36 degradation."
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"Subsequently , we found that UCHL1 inhibitor or siRNA downregulates the expression of CD36 protein whereas SR-A , ABCA1 , ABCG1 , Lox-1 , and SR-B1 have no significant change ."
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"UCHL1 KD also upregulated CD36 (Figure 5D) and downregulated lipase HSL (Figure 5E) and MAGL (Figure 5F) in C2C12 cells, potentially compensatory responses to the reduced perilipin 2 and possible low lipid content."
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