IndraLab

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USP1 inhibits FANCD2. 3 / 6
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"i) Recent studies have shown that several DNA repair proteins localize to the centrosome, and defects in these proteins cause several functional aberrations in centrosomes such as centrosome amplification.40-43 Also, it has been shown that DNA damage can induce centrosome amplification.41-43 Overexpression of Usp1 in NIH3T3 cells inhibited UV induced Fancd2-Ub and PCNA-Ub."
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"Depletion of Usp1 decreases epidermal proliferation in Fancd2 (+/-) mice."
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"However, in FA pathway, disruption of USP1 gene causes accumulation of the monoubiquitinated forms of FANCD2 and FANCI but increases ICL hypersensitivity and genomic instability [XREF_BIBR, XREF_BIBR]."
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