IndraLab

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Sulfenic acid activates KCNA5. 3 / 3
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"As expected, increasing sulfenic acid with tBOOH, or trapping this modification with dimedone, significantly increased internalization of Kv1.5 (XREF_FIG)."
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"Therefore, under acute oxidative stress, sulfenic acid modification triggers internalization of Kv1.5 and significantly reduces channel recycling back to the cell surface."
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"Furthermore, they showed that sulfenic acid modification of COOH terminal C581 alone is sufficient to trigger internalization and degradation of Kv1.5 (Svoboda et al., 2012)."
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