IndraLab

Statements

TLR4 binds CD274. 8 / 8
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"To limit off-target effects, the targeted membrane receptor, such as TLR4, PDL1, and peptide–MHC complex, should be as tumor-specific as possible [ xref ]."
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"Taken together, we conclude that expression of TLR4 in lung cancer is associated with PD-L1 and could predict the outcome of patients with NSCLC receiving pulmonary resection for cancer."
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"Therefore, it is hypothesized that the expression level of TLR4 is associated with PD-L1 in cancer cells."
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"In the present study, we assayed the expression level and association of TLR4 and PD-L1 in lung cancer tissues and evaluated the predicting role of TLR4 in cancer cells on postoperative survival in NSCLC patients receiving pulmonary lobectomy."
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"As shown in Figure xref C, the TLR4 expression level was significantly associated with PD-L1 level ( r  = 0.545, P  < 0.0001)."
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"Therefore, blocking the interaction between NKG2A and CD94 can activate NK-cell activity, further inhibiting the immune escape of cancer cells.Four immune checkpoint proteins, PD-L1, TLR4, HLA-G, and NKG2A, belong to the TMEM family and can form homodimers or heterodimers to regulate cancer immunotherapy."
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"BMDMs, on their part, had reduced levels of TLR-4, the pattern recognition receptor that binds LPS, interferon response factor 4 (IRF4) and PD-L1."
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"A positive association of TLR4 with PD-L1 in ccRCC was confirmed by Spearman correlation analysis (Figure xref B)."
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