IndraLab

Statements


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"The density of calcium currents mediated by Cav3.3 WT and HM variants was determined 24 h and/or 48 h post-transfection (Figure 1B; empty and filled symbols, respectively)."

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"There is evidence that a single copy of Chr22 :39665939 G> A CACNA1I triggers calcium channel disorder and is associated with the pathogenesis of SCZ [XREF_BIBR]."

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"Many of these risk genes encode proteins involved in calcium signaling including CACNA1C, CACNB2, and CACNA1I that may ultimately converge on a common disease mechanism XREF_BIBR, XREF_BIBR."

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"A high affinity peptide blocker for these Ca channels is the scorpion toxin kurtoxin which inhibits the Ca (v) 3.1 and Ca (v) 3.2, but not the Ca (v) 3.3 channel in nanomolar concentrations."