IndraLab

Statements

COPS6 decreases the amount of TRIM21. 4 / 4
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"In HCT116 cells, CSN6 reduced the steady-state level of TRIM21, and MLN4924 treatment reversed this effect."
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"We first identified that overexpression of CSN6 reduced the steady-state expression of TRIM21 in a dose dependent manner in the DLD-1 cell line."
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"In addition, knockdown of CSN6 increased TRIM21 protein levels."
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"45 Interestingly, CSN6 is able to decrease the steady-state expression of TRIM21 by enhancing TRIM21 ubiquitination, thereby promoting cancer stemness."
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