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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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COPS6 decreases the amount of TRIM21. 4 / 4

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"In HCT116 cells, CSN6 reduced the steady-state level of TRIM21, and MLN4924 treatment reversed this effect."

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"We first identified that overexpression of CSN6 reduced the steady-state expression of TRIM21 in a dose dependent manner in the DLD-1 cell line."

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"In addition, knockdown of CSN6 increased TRIM21 protein levels."

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"45 Interestingly, CSN6 is able to decrease the steady-state expression of TRIM21 by enhancing TRIM21 ubiquitination, thereby promoting cancer stemness."

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COPS6 decreases the amount of TRIM21. 4 / 4

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