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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUB1 activates TNFSF12. 2 / 2

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"Further , downregulation of ubiquitin thioesterase OTU domain ubiquitin aldehyde binding 1 ( OTUB1 ) enhances the degradation of cIAP1 and inhibits the TNF-related weak inducer of apoptosis ( TWEAK ) - induced MAPK and NF-kappaB pathway [ 33 ] ."

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"Downregulation of OTUB1 promotes TWEAK- and IAP antagonist stimulated caspase activation and cell death, and enhances c-IAP1 degradation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...