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YOD1 activates RIPK2. 4 / 4
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"Indeed, we found that, after blocking protein synthesis with CHX, YOD1 deletion accelerated the degradation of RIPK2 in BMDMs in the presence or absence of L18-MDP (Fig. 5G; Appendix Fig. S12A), indicating that YOD1 increases the stability of RIPK2 protein."
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"Consistently, YOD1 overexpression increased RIPK2 protein abundance and delayed RIPK2 degradation upon CHX treatment (Appendix Fig. S12B)."
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"Since RIPK2 is essential for NOD2 signaling and YOD1 stabilizes RIPK2, overexpression of YOD1 strongly increased L18-MDP-induced NF-κB and MAPK activation as well as cytokine production (Appendix Fig. S13)."
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"Altogether, these findings show that YOD1 enhances NOD2 signaling in macrophages by stabilizing RIPK2."
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