IndraLab

Statements

USP22 increases the amount of FOXP3. 4 / 4
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"Loss of Usp22 in Treg reduces Foxp3 transcript levels, increases FOXP3 ubiquitination and degradation, and reduces suppressive activity in vivo in mice."
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"Together with our recent discovery that Usp22 functions as a Foxp3-specific deubiquitinase, our data suggest that Usp22 promotes Foxp3 expression in itT cells (14)."
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"Targeted knockdown of USP22 in Treg cells using clustered regularly interspaced short palindromic repeats (CRISPR) technology reduces Foxp3 protein expression and inhibits tumor growth in multiple tum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Hypoxia selectively induces T reg Usp22, which supports Foxp3 expression."
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