IndraLab

Statements

USP8 activates Hedgehog. 4 / 6
| 4
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"Loss of USP8/UBPY blocked Hh-induced Smo accumulation whereas overexpression of USP8/UBPY resulted in ectopic Smo accumulation and Hh pathway activation [42,43]."
| PMC
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"However, the observation that USP8 and USP48 rather positively regulate HH signaling, whereas GNAS, MEN1, PRKAR1A, DICER1 and VHL rather negatively regulate this signaling pathway in PitNETs, does not allow a definitive conclusion, whether it is active or inactive HH signaling that is involved in formation of these tumors."
37476499
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"Finally, USP8 has been shown to increase Sonic Hedgehog (SHH) signaling by promoting SMO activity [27], even if the possible implications of this alteration have not been studied in USP8-mutated corticotrope adenoma cells to date (Figure 1)."
35743266
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"Although the loss-of-function of USP8 can block Hh induced cell surface accumulation of Smo, we found that USP8 only stabilizes Smo but does not regulate Smo phosphorylation in the absence of Hh (XREF_FIG), suggesting that the regulation of Smo by USP8 is downstream of Smo phosphorylation."
22253573