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KCNQ1 inhibits I Ks. 2 / 2
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"Therefore, KCNQ1 -G269S might minimally affect I Ks at rest but impair the up-regulation of I Ks by PKA, because the exercise stress (PKA activation) does not prolong the QTc interval in control subje[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Loss-of-function of I Ks by KCNQ1 variants causes type-1 long QT syndrome (LQTS)."