IndraLab

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ZUP1 inhibits DNA Damage. 2 / 2

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"Furthermore, loss of ZUFSP in human cancer cells led to increased endogenous DNA damage in these cells, and we could further show that this endogenous DNA damage originates in S-phase."

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"While WT ZUFSP effectively rescued the DNA damage phenotype in ZUFSP depleted cells, the C360S mutant was unable to, suggesting that the DUB activity of ZUFSP is required to prevent spontaneous DNA damage in cells (XREF_FIG F)."

29576527

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IndraLab

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ZUP1 inhibits DNA Damage. 2 / 2

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