IndraLab

Statements

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"These findings are in agreement with the observed decrease in LPS induced IKKbeta activity by estradiol in endothelial cells as well as the estradiol mediated reduction of IkappaBalpha phosphorylation in cerebral ischemia."
20351193
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"IRAK1-/- macrophages display decreased LPS induced IKKbeta activation and NF-kappaB DNA binding."
25290089
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"The time-course experiments revealed that LPS induced a gradual reduction of IKKbeta and IKKgamma proteins in BMMs from AR KO mice."
33771228
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"The knockdown experiments using siRNAs for IKKbeta, IRF4, and/or IRF8 indicated that LPS induced upregulation of IL-10 and IL-6 was reduced in IKKbeta knocked-down cells, and that the upregulation of IL-12 was suppressed by the knockdown of IRF4 and IRF8."
28893954
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"We found that TA-8 reduced NF-κB transcriptional activity and inhibited its entry into the nucleus, while reducing LPS-induced IKBKB expression upregulation and IκBα phosphorylation.Uncontrolled inflammatory immune response triggers up-regulation or down-regulation of protein expression in multiple pathways, involving cardiovascular, endocrine, neurological, metabolic, coagulation, energy metabolism, etc., which leads to tissue hypoxia, mitochondrial dysfunction, and cell death and subsequently leads to impaired organ function (Tidswell and Singer, 2018)."
32153412
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"Thus to differentiate the downstream effects of IKKbeta-p105-NFkappaBp50 and IKKbeta-p105-ERK pathways and further to demonstrate that the enhanced cytokine responses observed in the GRK2 Deltamye cells are mediated via these pathways, we examined LPS induced cytokine responses using pharmacological inhibitors of MEK-ERK (PD98059) and IKKbeta (BMS345541)."
20717897
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"Additionally, XD inhibited inflammatory response in LPS stimulated BEAS-2B cells possibly by blocking IKBKB and NF-kappaB signal pathway which was regulated by miR-15a."
29710526