IndraLab

Statements

USP1 inhibits CHEK1. 2 / 4
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"Other USP1 activities include involvement in a feedback loop to limit DDR CHK1 protein kinase activity , and the regulation of cellular differentiation in osteosarcoma cells by deubiquitylating and hence affecting the stability of inhibitors of DNA-binding proteins ."
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"The first of these is the loss or alteration of CHK1 signalling mediated, at least in part, by loss of USP1 [20] or Claspin expression [18] (Figure 6)."
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