IndraLab

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USP1 inhibits CHEK1. 2 / 4
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"Other USP1 activities include involvement in a feedback loop to limit DDR CHK1 protein kinase activity , and the regulation of cellular differentiation in osteosarcoma cells by deubiquitylating and hence affecting the stability of inhibitors of DNA-binding proteins ."

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"Other USP1 activities include involvement in a feedback loop to limit DDR CHK1 protein kinase activity 72 , and the regulation of cellular differentiation in osteosarcoma cells by deubiquitylating and hence affecting the stability of inhibitors of DNA-binding proteins 73 ."