IndraLab

Statements

OTUB1 deubiquitinates CTNNB1. 3 / 3
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"Mechanistically, we uncovered that OTUB1 exerts its influence by deubiquitinating and stabilizing beta-catenin, leading to its nuclear translocation."
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"In summary, OTUB1 deubiquitinates and stabilizes β-catenin, and accumulated β-catenin enters the nucleus and further promotes the transcription process of downstream targets, thus facilitating the tumorigenesis and cisplatin resistance of BLCA (Fig. 8F)."
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"Mechanistically, OTUB1 deubiquitinates and stabilizes β-catenin, leading to transcriptional upregulation of c-myc and cyclin D1 while downregulating RIPK3 and MLKL, ultimately driving tumorigenesis and cisplatin resistance in BLCA."
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