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Sevoflurane inhibits NLRP3. 11 / 11
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"Sevoflurane attenuates cognitive dysfunction and NLRP3 dependent caspase-1/11-GSDMD pathway mediated pyroptosis in the hippocampus"
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"However, whether sevoflurane inhibits the Th2 response and NLRP3 inflammasome activation in allergic airway inflammation remains unknown.In the present study, we investigated whether sevoflurane inhibits the activation of the NLRP3 inflammasome to mitigate allergic airway inflammation."
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"Taken together, we concluded that sevoflurane activated the AMPK/ULK1 pathway to trigger autophagic flux and suppress NLRP3-mediated pyroptotic cell death in I/R or H/R-treated cardiomyocytes, which further ameliorated myocardial I/R injury."
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"Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation Background Our colleagues have demonstrated an impressive therapeutic role of sevoflurane in a murine allergic airway inflammation model , but the mechanisms underlying this effect remain undefined ."
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"Specifically, sevoflurane conditioning suppressed NLRP3 and cleaved caspase-1 expressions to inactivate cell pyroptosis, upregulated LC3B-II/I ratio, facilitated autophagosome formation and accelerated p62 degradation to trigger autophagy, and promoted the expressions of CDK2, CDK6 and Cyclin D1 to recover cell cycle in I/R mouse myocardial tissues in vivo and hypoxic/re-oxygenated (H/R) cardiomyocytes in vitro."
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"Furthermore, sevoflurane, similar to MCC950, clearly inhibited the OVA induced activity of NLRP3 in the lungs."
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"Furthermore, sevoflurane, similar to MCC950, clearly inhibited the OVA-induced activity of NLRP3 in the lungs."
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"These results suggested that NLRP3 mediated allergic airway inflammation independently of inflammasome activation, while sevoflurane inhibited the activity of NLRP3 to alleviate airway inflammation."
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"Recently, it has been reported that NLRP3 acts as a key transcription factor in Th2 differentiation in asthma models [8], suggesting that sevoflurane may inhibit Th2 responses via NLRP3 in our model.In conclusion, our study suggests that the protective effect of sevoflurane on allergic airway inflammation is at least partly explained by the inhibition of Th2 cytokines and NLRP3 expression."
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"Furthermore, sevoflurane inhibited the OVA-induced activity of NLRP3 in the lungs, which is similar to that of MCC950-treated allergic mice."
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"Chikusetsu saponin IVa alleviated sevoflurane induced neuroinflammation and cognitive impairment by blocking NLRP3 and caspase -1 pathway."
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