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Sevoflurane inhibits NLRP3. 15 / 15
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"The above results suggest that sevoflurane alleviates LPS-induced ALI through inhibiting pyroptosis.Various upstream signaling pathways, including PI3K/Akt and GSK-3β, can impact the NLRP3 inflammasom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This effect is similar to that of sevoflurane, which was found to attenuate cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus [ 34 ]."
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"Sevoflurane has been recently reported to activate GSK-3β to suppress the NLRP3 inflammasome."
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"And Chen et al. indicated that sevoflurane could attenuate cognitive dysfunction via NLRP3-dependent pyroptosis in a sepsis mice model [28] ."
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"These results suggested that NLRP3 mediated allergic airway inflammation independently of inflammasome activation, while sevoflurane inhibited the activity of NLRP3 to alleviate airway inflammation."
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"Furthermore, sevoflurane inhibited the OVA-induced activity of NLRP3 in the lungs, which is similar to that of MCC950-treated allergic mice."
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"Sevoflurane inhibits pyroptosis by suppressing the P2X7/NLRP3 pathway ( Wu et al., 2021 )."
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"Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation Background Our colleagues have demonstrated an impressive therapeutic role of sevoflurane in a murine allergic airway inflammation model , but the mechanisms underlying this effect remain undefined ."
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"Lin et al. found that the administration of sevoflurane 2 min before reperfusion further inhibited NLRP3 activation by activating AMPK/ULK1-mediated autophagic flux, thereby ameliorating MI/R injury i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Chikusetsu saponin IVa alleviated sevoflurane induced neuroinflammation and cognitive impairment by blocking NLRP3 and caspase -1 pathway."
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"Sevoflurane attenuates cognitive dysfunction and NLRP3 dependent caspase-1/11-GSDMD pathway mediated pyroptosis in the hippocampus"
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"Recently, it has been reported that NLRP3 acts as a key transcription factor in Th2 differentiation in asthma models [8], suggesting that sevoflurane may inhibit Th2 responses via NLRP3 in our model.In conclusion, our study suggests that the protective effect of sevoflurane on allergic airway inflammation is at least partly explained by the inhibition of Th2 cytokines and NLRP3 expression."
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"Furthermore, sevoflurane, similar to MCC950, clearly inhibited the OVA-induced activity of NLRP3 in the lungs."
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"Our present study suggested that sevoflurane suppressed the activation of NLRP3 inflammasome and the subsequent inflammation."
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"However, whether sevoflurane inhibits the Th2 response and NLRP3 inflammasome activation in allergic airway inflammation remains unknown.In the present study, we investigated whether sevoflurane inhibits the activation of the NLRP3 inflammasome to mitigate allergic airway inflammation."
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