IndraLab

Statements

CALM1 activates PPP3CA. 4 / 4
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sparser
"The increase of calcium ion concentration directly activates CAM, which in turn activates CnA and CnB."
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reach
"In response to an external cue, intracellular Ca binds to the calmodulin protein (Cam1), which then activates the calcineurin phosphatase complex (Cna1 and Cnb1)."
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signor
"Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain."
11796223
sparser
"In C. neoformans , Cna1 is activated by Cam1 and plays an important role in growth at 37 °C. Under elevated temperatures, Cna1 targets a Crz1 ortholog; the Cna1-Crz1 pathway is required for expression of chitin synthase genes CHS5 and CHS6 , with a role in cell wall structure and fungal cell survival during infection [ xref ]."
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