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BRAF increases the amount of USP15. 2 / 2
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"Comparably, pharmacological inhibition of BRAF or ERK1/2 also significantly down-regulated USP15 expressions in BRAF -mutated human thyroid cancer cells (Fig. 4b and Supplementary Fig. 3a)."
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"Together, USP15, downstream of activated BRAF/MAPK pathway, functions as the proteostatic controller of TBX3 and determines the ultimate abundance.Remarkably, induction of Usp15 expression by BRAF/MAPK could be instant and dramatic, so that its level was augmented in E16.5 embryonic thyroid from mPTC mice compared to that from wild-type mice (Fig. 4f and Supplementary Fig. 3c)."
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