IndraLab

Statements

BRCC3 deubiquitinates NLRP6. 3 / 3
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"33 Notably, BRCC3 deubiquitinated NLRP6; however, BRCC3 facilitated NLRP6 and ASC assembly, inconsistent with the role of Cyld."
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"Moreover, both BRCC3 and its N- and C-terminals interacted with NLRP6, and both BRCC3 and its terminals reduced NLRP6 ubiquitination."
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"We found that BRCC3 decreased the ubiquitination of NLRP6 in HEK293T cells and that this effect was associated with both the N‐ and C‐terminal of BRCC3 (Figure 5C,D)."
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