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Nitric oxide inhibits STAT1. 6 / 6
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"In another study, daidzein could significantly down-regulate LPS-induced NO and IL-6 production by inhibiting NF-κB and STAT1 pathway in RAW264.7 murine macrophages [14] ."
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"Thus, TRIM59 affects the NO production via downregulating JAK2/STAT1 signaling pathway.Next we investigated whether TRIM59 as an intracellular regulator interacted with downstream mediators to carry o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overall, this research indicates that beta-glucan inhibits the production of the NO in the E. coli LPS activated murine macrophages via the HO-1 induction and inhibits the STAT1 signaling pathways."
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"As previously reported, Catalpalactone can inhibit the NO synthase (iNOS) expression and the production of NO, IL6 and tumor necrosis factor-α in the lipopolysaccharide-induced macrophage, and regulate the anti-inflammatory signaling, such as inhibiting STAT-1, IFN-β and IRF3 activation, to play a cytoprotecting role [21]."
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"Furthermore, addition of this NO donor also reduced formation of CD14 ++ CD209 + cells and activation of STAT3 (Y05), STAT3 (S727), and STAT1."
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"Inhibition of PKC activity by Go 6976 prevented HG-induced increases of phosphor-Erk1/2 and nitric oxide synthase (NOS1) expressions as well as hyperpermeability, whereas inhibition of p38MAPK pathway by SB203580 selectively suppressed activation of STAT1 and decreased apoptotic cell death under HG conditions."
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