IndraLab

Statements


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"Overall, this research indicates that beta-glucan inhibits the production of the NO in the E. coli LPS activated murine macrophages via the HO-1 induction and inhibits the STAT1 signaling pathways."

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"Inhibition of PKC activity by Go 6976 prevented HG-induced increases of phosphor-Erk1/2 and nitric oxide synthase (NOS1) expressions as well as hyperpermeability, whereas inhibition of p38MAPK pathway by SB203580 selectively suppressed activation of STAT1 and decreased apoptotic cell death under HG conditions."

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"Finally, NO donors inhibited nuclear factor-kappa B and STAT-1, but not AP-1 activities in transiently transfected keratinocytes."

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"Furthermore, addition of this NO donor also reduced formation of CD14 ++ CD209 + cells and activation of STAT3 (Y05), STAT3 (S727), and STAT1."