IndraLab

Statements

BAP1 binds FOXK1. 24 / 24
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"Thus, O-GlcNacylated FOXK1 associates with BAP1 and promote E2F pathway and oncogenesis."
38463952
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"BAP1 also associates with transcription factors, including FOXK1, FOXK2, and Yin Yang1 (YY1), which ensure the recruitment of this DUB to chromatin (133, 142)."
35764170
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"Here the authors find that the O-GlcNAcylated FOXK1 associates with the deubiquitinase BAP1 to upregulate transcription of E2F target genes and promote cancer progression."
40593803
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32509391
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"By comparing BAP1 recruitment in IMR90 cells expressing FOXK1 with those expressing FOXK1 , we identified 2,130 regions showing reduced recruitment of BAP1 in FOXK1 (Fig. 6e)."
38463952
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"For example, analysis of 407 pleural mesothelioma cases and 389 controls with a comprehensive history of asbestos exposure revealed an increased risk of abnormalities in chromosomal region 7p22.2, which includes the gene encoding the Forkhead box protein K1 (FOXK1) that interacts with BAP1 [ xref ]."
| PMC
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25609649
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"To provide further insight into the relevance of FOXK1-BAP1 interaction in the context of cancer, we transduced pleural mesothelioma and lung cancer cell lines, that are BAP1-proficient or BAP1-deficient xref , with either FOXK1 or its O-GlcNAcylation-defective mutant."
40593803
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"Although BAP1 interacts with a transcriptional regulator, HCF-1, and transcription factors FoxK1 and FoxK2, how BAP1 controls gene expression remains unclear."
25451922
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"Thus, O-GlcNAcylated FOXK1 associates with BAP1 and promotes E2F pathway and oncogenesis."
40593803
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33961781
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34591877
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"This post-translational modification introduces a second interaction module, stabilizing the overall interaction of BAP1 with FOXK1."
40593803
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25451922
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"For instance, during the G1/S transition, time at which the transcriptional activation of E2F target genes is critical, increased O-GlcNAcylation of FOXK1 might favor BAP1-FOXK1 complexes at the expense of BAP1-FOXK2 complexes."
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"Thus, BAP1-FOXK1 interaction might constitute a therapeutic opportunity in BAP1 positive mesothelioma tumors."
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"In conclusion, while our studies provided important insights into the role of O-GlcNAcylation in the regulation of FOXK1-BAP1 interaction and the E2F pathway, it remains to be determined how the interplay between these factors impacts transcription and balances BAP1 deubiquitinase activity during tumor development or suppression."
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19615732
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20805357