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COPS6 inhibits steady-state TRIM21. 2 / 2
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"Tripartite motif ( TRIM ) protein family members ( numbering > 70 ) have been implicated in various cellular functions , including cell proliferation , differentiation , development , apoptosis , antiviral activity , autophagy and oncogenesis.44 TRIM21 plays a pivotal role in immune activation during pathogen infection , but its cellular function remains unclear.45 Interestingly , CSN6 is able to decrease the steady-state expression of TRIM21 by enhancing TRIM21 ubiquitination , thereby promoting cancer stemness ."
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"In HCT116 cells , CSN6 reduced the steady-state level of TRIM21 , and MLN4924 treatment reversed this effect ( Fig. 3g ) ."
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