IndraLab

Statements

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"Deficiency of USP7 impairs human terminal erythroid differentiation."
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"Further, Tang et al. found that USP7 promoted osteogenic differentiation of human adipose-derived stem cells through its catalytic activity [ 5 ]."
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"The USP7 selective small-molecule inhibitors P5091 and P22077 inhibited cell proliferation and induced megakaryocytic differentiation in both cell lines and primary cells."
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"Immunofluorescent staining showed that ectopic expression of Wt-HAUSP but not the Mt-HAUSP almost fully rescued the differentiation phenotype induced by knockdown of endogenous HAUSP with the B5 shHAUSP (XREF_FIG)."
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"Accordingly, Hausp deficient osteoblasts were refractory to RUNX2 induced transcriptional activation and osteoblast differentiation."
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"Moreover, deubiquitination assay demonstrated that expression of Wt-HAUSP but not the Mt-HAUSP attenuated the REST ubiquitination induced by B5 shHAUSP (XREF_FIG), showing that Wt-HAUSP functioned through deubiquitination to stabilize REST and rescued the differentiation phenotype induced by knockdown of endogenous HAUSP."
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"43 In conclusion , our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7 , which potentially suppress the osteoblast proliferation , differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression ( Figure 7 ) ."
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"3.5 USP7 promoted osteoblast differentiation and autophagy to ameliorate osteoporosis by increasing KDM6B expression."
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"Upregulation of USP7 enhances osteogenic differentiation in human adipose-derived stem cells (hASCs) to suppress osteogenesis progression."
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"Genetic depletion of USP7 by lentiviral RNAi markedly suppressed hASC osteogenesis both in vitro and in vivo, while overexpression of USP7 enhanced the osteogenic differentiation of hASCs."
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"Therefore, the obtained data suggested that USP7 could induce osteoblast differentiation and autophagy to ameliorate osteoporosis by increasing KDM6B expression."
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"Taken together, these results indicated that USP7 knockdown inhibits osteogenic differentiation of hASCs in vitro."
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"Hence, abaloparatide partly reversed the inhibition of cell proliferation and chondrogenic differentiation by USP7 knockdown.Moreover, the CCK8 assay and Alcian blue, toluidine blue, and ALP stainings[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of USP7 promotes osteogenic differentiation of hASCs in vitro."
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"Taken together, these results indicated that USP7 promotes osteogenic differentiation of hASCs in vitro."
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"Down-regulation of USP7 or pharmacological inhibition impairs muscle differentiation by affecting myogenin stability, thereby enhancing SC myogenic progression [114]."
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"We found that USP7 is necessary for the differentiation and proliferation of the somatic cell lineages of both ovaries and testes."
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"32 Accumulating evidence has also elucidated that up-regulation of USP7 could enhance the osteogenic differentiation of human adipose derived stem cells (hASCs) to inhibit the progression of osteogenesis, 20 suggesting that overexpression of USP7 could relieve atherosclerosis."
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"We demonstrated that this bioactive inhibitor of USP7 significantly facilitated repression of osteogenic genes, and consequently inhibited osteogenic differentiation of hASCs."
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"Thus, these findings support that restoration of USP7 underlies the anti-osteogenic effect of miR-15b by stimulating osteoblast proliferation, differentiation, and autophagy."
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"36 Of note, our data revealed that inhibition of proteasome up-regulated expression of USP7 and KDM6B, while increased USP7 expression promoted osteoblast differentiation and autophagy, alleviating osteoporosis."
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"Collectively, these results demonstrate that Ihh/Smo promotes PTHrP/PTH1R signalling to modulate chondrocyte proliferation and chondrogenic differentiation but Ihh/Smo enhances the hypertrophic differ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
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"Mechanistically, RNA-seq results showed that Usp7 negatively regulated FGSC self-renewal but positively modulated differentiation in FGSCs."
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"To further causally link REST regulation to the effect of HAUSP on preventing NPC differentiation, we attempted to rescue the differentiation phenotype induced by HAUSP knockdown by overexpressing REST."
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"USP7 inhibition impairs beta-cell differentiation in hiPSC-derived pancreas organoids."
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"In the future, it would be better to use an Ihh-specific inhibitor.In conclusion, our study indicated that USP7 knockdown or its inhibition inhibits chondrocyte proliferation and chondrogenic differen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP7 inhibition inhibits proliferation and induces megakaryocytic differentiation in MDS cells by upregulating gelsolin."
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"In this study, we demonstrated that inhibition of protein deubiquitinase USP7 suppressed osteogenic differentiation of hASCs in a catalytic activity dependent manner, while overexpression of USP7 enhanced hASC osteogenesis."
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"Inactivation of Usp7 in Apc Mutated Intestinal Organoids Promotes Differentiation and Suppresses Growth."
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"Our results indicate that USP7 knockdown inhibited proliferation and chondrogenic differentiation but promoted the hypertrophic differentiation of ATDC5 cells, both in vitro and in vivo."
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"Since USP7 acts to remove ubiquitination of histone H2B120 lysine (H2BK120Ub) and usually associates with gene transcription repression complex [XREF_BIBR, XREF_BIBR], it is unlikely that USP7 promotes osteogenic differentiation through directly regulating transcription of osteogenic associated genes."
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"USP7 also interacted with SOX9 and modulated the proliferation and differentiation of mouse embryonic tumor cells [28]."
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"As shown in Figure 1D, USP7 knockdown impaired the terminal erythroid differentiation as demonstrated by the decreased surface expression of the erythroid marker GPA, delayed loss of α4-integrin expression in association with decreased surface expression of band 3."
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"However, to the best of our knowledge, no studies have evaluated the mechanism and function of Usp7 in determining FGSC self-renewal and differentiation.In this paper, we report for the first time that Usp7 inhibited the proliferation of FGSCs and promoted their differentiation via genomic methylation."
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"Usp7 deficiency inhibits the stem cell proliferation and differentiation."
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"Based on the experiments’ results, we confirmed that Usp7 deficiency restricted the stem cell proliferation and differentiation in regenerative worms."
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"Thus, the possible mechanism by which USP7 upregulates osteogenic differentiation of hASCs might be that USP7 stabilizes PHF8."
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"In this study, USP7 depletion and P5091 were shown to inhibit inflammation in senescent bone marrow-derived macrophages (BMDMs) and promote osteogenic differentiation in aged bone marrow mesenchymal stromal cells (BMSCs)."
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"Our results showed that Usp7 overexpression negatively regulates FGSC self-renewal but positively modulates differentiation in FGSCs."
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"Moreover, USP7 is necessary for osteogenic differentiation of human adipose-derived stem cells (hASCs) [22]."
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"Our study revealed that Usp7 overexpression induces FGSC differentiation."
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"Nevertheless, whether USP7 can function as a USP15 to modulate Th cell differentiation warrants further research.Th17 cells serve as ‘Jekyll and Hyde’ cells in tumor progression due to their strong plasticity [75, 76]."
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"Knockdown of USP7 inhibits chondrogenic differentiation of ATDC5 cells but promotes hypertrophic differentiation [23]."
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"Moreover, during osteogenic differentiation, we observed a decrease in USP7 protein levels, and USP7 knockdown suppressed osteogenic differentiation (Figure 2E)."
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"Altogether, these results showed that USP7 knockdown suppresses osteogenic, adipogenic, and chondrogenic differentiation, suggesting that USP7 is essential for hBMSC differentiation."
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"Silencing USP7 decreases the differentiation potential of mouse 3T3-L1 [21], hASCs [22], and ATDC5 cells [23]."
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"We demonstrate that USP7 promotes the differentiation of CD14+ PBMCs into osteoclasts via HMGB1 deubiquitination and that inhibition of USP7 effectively attenuates bone loss in osteoporosis in vivo.The translational potential of this article:The study reveals novel insights into the role of USP7 in the progression of osteoporosis and provides a new therapeutic target for the treatment of osteoporosis."
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"USP7 depletion leads to impaired osteogenic differentiation of hASCs."
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"For example, USP44 and USP7 appeared to promote FOXP3 function in regulating Th17- and Treg-cell differentiation (11, 12)."
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"To confirm this hypothesis, we analyzed the expression of Usp7 in both the control group and the Usp7 KO group at different days during RA-induced differentiation."
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