IndraLab

Statements

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"Since USP7 acts to remove ubiquitination of histone H2B120 lysine (H2BK120Ub) and usually associates with gene transcription repression complex [XREF_BIBR, XREF_BIBR], it is unlikely that USP7 promotes osteogenic differentiation through directly regulating transcription of osteogenic associated genes."
28807012
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"32 Accumulating evidence has also elucidated that up-regulation of USP7 could enhance the osteogenic differentiation of human adipose derived stem cells (hASCs) to inhibit the progression of osteogenesis, 20 suggesting that overexpression of USP7 could relieve atherosclerosis."
33434305
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"In conclusion, USP7 modulates the proliferation and differentiation of ATDC5 cells via the Sox9-PTHrP-PTH1R axis."
33127578
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"Taken together, these results indicated that USP7 promotes osteogenic differentiation of hASCs in vitro."
28807012
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"Accordingly, Hausp deficient osteoblasts were refractory to RUNX2 induced transcriptional activation and osteoblast differentiation."
32385263
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"The USP7 selective small-molecule inhibitors P5091 and P22077 inhibited cell proliferation and induced megakaryocytic differentiation in both cell lines and primary cells."
32130729
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"3.5 USP7 promoted osteoblast differentiation and autophagy to ameliorate osteoporosis by increasing KDM6B expression."
33434305
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"Thus, these findings support that restoration of USP7 underlies the anti-osteogenic effect of miR-15b by stimulating osteoblast proliferation, differentiation, and autophagy."
33434305
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"43 In conclusion , our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7 , which potentially suppress the osteoblast proliferation , differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression ( Figure 7 ) ."
33434305
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"However, to the best of our knowledge, no studies have evaluated the mechanism and function of Usp7 in determining FGSC self-renewal and differentiation.In this paper, we report for the first time that Usp7 inhibited the proliferation of FGSCs and promoted their differentiation via genomic methylation."
33151468
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"Mechanistically, RNA-seq results showed that Usp7 negatively regulated FGSC self-renewal but positively modulated differentiation in FGSCs."
33151468
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"In this study, we demonstrated that inhibition of protein deubiquitinase USP7 suppressed osteogenic differentiation of hASCs in a catalytic activity dependent manner, while overexpression of USP7 enhanced hASC osteogenesis."
28807012
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"USP7 inhibition inhibits proliferation and induces megakaryocytic differentiation in MDS cells by upregulating gelsolin."
32130729
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"Genetic depletion of USP7 by lentiviral RNAi markedly suppressed hASC osteogenesis both in vitro and in vivo, while overexpression of USP7 enhanced the osteogenic differentiation of hASCs."
28807012
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"Thus, the possible mechanism by which USP7 upregulates osteogenic differentiation of hASCs might be that USP7 stabilizes PHF8."
30123285
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"Overexpression of USP7 promotes osteogenic differentiation of hASCs in vitro."
28807012
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"Inactivation of Usp7 in Apc Mutated Intestinal Organoids Promotes Differentiation and Suppresses Growth."
29045831
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"We demonstrate that USP7 promotes the differentiation of CD14+ PBMCs into osteoclasts via HMGB1 deubiquitination and that inhibition of USP7 effectively attenuates bone loss in osteoporosis in vivo."
37333461
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"36 Of note, our data revealed that inhibition of proteasome up-regulated expression of USP7 and KDM6B, while increased USP7 expression promoted osteoblast differentiation and autophagy, alleviating osteoporosis."
33434305
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"Immunofluorescent staining showed that ectopic expression of Wt-HAUSP but not the Mt-HAUSP almost fully rescued the differentiation phenotype induced by knockdown of endogenous HAUSP with the B5 shHAUSP (XREF_FIG)."
21258371
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"USP7 knockdown or its inhibitor suppressed cell proliferation and chondrogenic differentiation but improved hypertrophic differentiation."
33127578
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"We demonstrated that this bioactive inhibitor of USP7 significantly facilitated repression of osteogenic genes, and consequently inhibited osteogenic differentiation of hASCs."
28807012
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"USP7 depletion leads to impaired osteogenic differentiation of hASCs."
30123285
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"To further causally link REST regulation to the effect of HAUSP on preventing NPC differentiation, we attempted to rescue the differentiation phenotype induced by HAUSP knockdown by overexpressing REST."
21258371
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"Our study revealed that Usp7 overexpression induces FGSC differentiation."
33151468
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"Taken together, these results indicated that USP7 knockdown inhibits osteogenic differentiation of hASCs in vitro."
28807012
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
33434305
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"Our results showed that Usp7 overexpression negatively regulates FGSC self-renewal but positively modulates differentiation in FGSCs."
33151468
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"Therefore, the obtained data suggested that USP7 could induce osteoblast differentiation and autophagy to ameliorate osteoporosis by increasing KDM6B expression."
33434305
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"Moreover, deubiquitination assay demonstrated that expression of Wt-HAUSP but not the Mt-HAUSP attenuated the REST ubiquitination induced by B5 shHAUSP (XREF_FIG), showing that Wt-HAUSP functioned through deubiquitination to stabilize REST and rescued the differentiation phenotype induced by knockdown of endogenous HAUSP."
21258371