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Allopurinol inhibits NLRP3. 8 / 8
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"In addition to showing allopurinol reduced oxidative stress markers, NLRP3, and IL-1β, a streptozotocin-induced diabetic rat model revealed that allopurinol administration decreased hyperglycemia-induced retinal leukostasis, and restored retinal blood-barrier function (15)."
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"Moreover , allopurinol , an inhibitor of XO , reduced NLRP3 expression ."
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"For example, in streptozotocin-diabetic rats, the use of quercetin and allopurinol for 7 weeks inhibits the activation of NLRP3, PPARa, and up-regulation of sterol regulatory element-binding protein-1c (SREBP-1c) by TXNIP down-regulation in the liver, showing less hepatic lipid accumulation [190]."
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"These results were supported by in vivo studies, where curcumin (15, 30 and 60 mg/kg) and allopurinol (5 mg/kg) inhibited the activation of TXNIP/NLRP3 inflammasomes by up-regulating miR-200a in the l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has also been shown that allopurinol reduces the activation of NLRP 3 by lowering UA."
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"Allopurinol significantly inhibited NLRP3 expression ."
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"In this regard, Wang et al. [28] showed that allopurinol inhibited the activation of NLRP3 inflammasome and alleviated inflammatory responses in the liver of diabetic rats."
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"Furthermore, treatment with allopurinol and notopterol from the second week post-hyperuricemia induction for four weeks attenuated cardiac dysfunction and suppressed NLRP3 activation and inflammatory cytokine production in cardiac tissue of hyperuricemic mice."
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