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Allopurinol inhibits NLRP3. 3 / 3
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"For example, in streptozotocin-diabetic rats, the use of quercetin and allopurinol for 7 weeks inhibits the activation of NLRP3, PPARa, and up-regulation of sterol regulatory element-binding protein-1c (SREBP-1c) by TXNIP down-regulation in the liver, showing less hepatic lipid accumulation [190]."