IndraLab

Statements

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"Hence, we treated cells with cycloheximide, a protein synthesis inhibitor, to block the production of NLRP3 and assessed the protein decay over time."
36788033
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"To test this hypothesis, we evaluated NLRP3 stability in BMDMs using the protein synthesis pan-inhibitor cycloheximide (CHX), which demonstrated that PV-K treatment (PV-K + LPS + ATP) enhanced NLRP3 degradation (Fig. 6C, D)."
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"To further elucidate whether oroxylin A could affect the inflammasome formation in the second step, cycloheximide was given before LPS to block NLRP3 protein synthesis."
28938606
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"As previously shown, NLRP3 inflammasome activation was critically dependent on the presence of LPS and abrogated by cycloheximide treatment (XREF_FIG, upper panel)."
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