IndraLab

Statements

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"In 2019, Zhang et al. showed that USP4 inhibition prevented the activity of the TGF-β/Smad signaling pathway (40)."
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"USP20 and USP4 promote the stability of β-catenin, thus continuously activating the Wnt-β-catenin signaling pathway and mediating drug resistance in breast cancer and CRC ( Fig. 3 )."
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"Western blot analyses showed that TRAF6 knockdown in USP4 overexpression PC cell lines can change the protein levels of cell proliferation molecules and also reverse the activation of NF-κB signaling [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in previous studies [XREF_BIBR], USP4 is an effective inducer of TGF-beta signal transduction, which interacts directly with TGF-betaR1 and acts as a de-ubiquitinase enzyme to maintain the level of TGF-betaR1 on the plasma membrane."
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"The hypothesis that drove this study was that USP4 might also mediate the TGF-beta signal transduction pathway in hypertrophic scar fibroblasts."
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"However, when it comes to tumor metastasis, USP4 can promote breast cancer cells metastasis by activating TGF-β1/Smad2/matrix metalloproteinase-9 signaling pathway [ 33 ]."
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"LncRNA H19 targets miR-148a, increases deubiquitinating enzyme USP4 expression, activates the TGF-β signaling pathway in hepatic stellate cells and hepatocytes, and exacerbates hepatic fibrosis 180."
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"USP4 can target the TGF-β receptor for deubiquitination and enhance the activation of the TGF-β/BMP signaling pathway to promote the proliferation and differentiation of MSCs (69)."
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"It was also found that USP4 inhibited NF-kappaB activation, but in this study we confirmed that USP4 positively regulates the NF-kappaB signalling pathway during EV71 infection."
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"Our results showed that USP4 positively regulates the MER/ERK signaling pathway via a TAK1-dependent process."
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