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OLR1 activates TLR4. 13 / 13
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"Ox-LDL is the main form of LDL inducing the formation of foam cells and activates Toll-like receptor 4 (TLR4) to participate in inflammatory AS (T. W. Chen et al., 2020 )."
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"Similarly, oxLDL activates TLR4, triggering inflammatory response in macrophages through mitogen-activated protein kinase (MAPK) pathway [5] ."
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"These results are consistent with previous findings that TLR4 is activated by Ox-LDL in VSMCs and macrophages ( Xu et al., 2001; Yang et al., 2014 )."
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"OxLDL activates TLR4 and thereby initiates a macrophage inflammatory response with the production of proinflammatory cytokines resulting in vascular inflammation [44,51,71] ."
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"Although the specific mechanism of TLR4 activation by oxLDL is not known, it appears that MD2 is likely required."
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"Yet, the oxLDL-induced activation of TLR4 is increasingly recognized as an important pathogenic basis of chronic inflammatory diseases, linking obesity (and the metabolic syndrome) to sterile inflamma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NLRP3 activation has been indicated at the crossroad between inflammation and cholesterol dysmetabolism since cholesterol crystals [ xref ] and ox-LDL [ xref ] activate TLR4, ultimately promoting NLRP3 inflammasome aggregation."
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"In mouse primary macrophages, MD2 is not involved in oxLDL uptake, but it is critical for ox-LDL induced TLR4 activation [ 59 ]."
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"In vitro studies showed that stimulation of LSECs with ox-LDL and palmitate activated NF-kB and TLR-4, respectively [ xref , xref , xref ]."
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"Future studies are needed to fully elucidate how oxLDL activates the MD2-TLR4 immune signaling complex."
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"However, whether oxLDL binds to and activates the TLR4 was not investigated."
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"We concluded that CK(-) granulosa cells are protected against oxLDL-dependent apoptosis by TLR4, whereas, in CK(+) cells, oxLDL-induced TLR4 activation triggers nonapoptotic cell death."
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"Ox-LDL activates Toll-like receptor 4 (TLR4) in VSMCs and upregulates ACAT1 expression via the TLR4/myeloid differentiation primary response 88(MyD88)/nuclear transcription factor kappa B (NF-B) inflammatory signaling pathway, ultimately promoting the formation of VSMC-derived foam cells [ xref ]."
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