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USP8 deubiquitinates SEC31A. 5 / 6
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"In this study, we showed that USP8 deubiquitinates Sec31A and restricts the intracellular transport of collagen IV.USP8 can bind to STAM1 and STAM2 [ 16 ], and STAM1 can bind to Sec31A [ 26 ]."
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"In this study, we show that USP8 deubiquitinates Sec31A and regulates the formation of large COPII carriers and collagen IV transport.HEK293T, HeLa, and COS7 cells were grown in Dulbecco's modified Ea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Sec31A ubiquitination was not affected by the catalytically inactive form of USP8 (CA) [ 21 ], and was decreased more intensely by the hyperactive form of USP8 (PR) [ 22 ] ( Fig. 2 A)."
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"As a result, the interaction of USP8 710−1110 with Sec31A was observed only when we used the lysates of cells overexpressing STAM1 ( Fig. 1 E), demonstrating that STAM1, but not STAM2, enables the int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we show that USP8 deubiquitinates Sec31A, modulates COPII carrier formation, and restricts collagen IV secretion."
29604273