IndraLab

Statements

UCHL1 activates HIF1A. 5 / 6
| 5
reach
"In 2D monolayer culture, a UCHL1 inhibitor suppressed HIF activity and decreased the transcription of HIF downstream genes by inhibiting the UCHL1-mediated accumulation of HIF-1alpha."
31729096
reach
"UCHL1 increases the stability of HIF-1alpha."
25615526
reach
"Integrin alpha6beta4 Upregulates PTPRZ1 Through UCHL1-Mediated Hif-1alpha Nuclear Accumulation to Promote Triple-Negative Breast Cancer Cell Invasive Properties."
39518121
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"In addition, UCHL1 enhances the activity of hypoxia-inducible factor 1-alpha (HIF1α) by regulating its degradation, which is ubiquitinated by von Hippel–Lindau (pVHL) E3 ubiquitin ligase."
36681249
reach
"XREF_BIBR, XREF_BIBR Work from the field of oncological science indicated UCHL1 might prevent HIF-1alpha degradation."
25937996