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ASXL2 activates BAP1. 3 / 3
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"The DEUBAD domains of ASXL1, ASXL2 and ASXL3 can activate BAP1 by increasing its affinity for ubiquitin."
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"In this paper we describe that similar to the homologous UCH-L5 and RPN13 DEU complex, the DEUBAD domains of ASXL1, ASXL2 and ASXL3 can activate BAP1 by increasing BAP1 's affinity specifically for the ubiquitin in the substrate, through a combination of mild effects."
26739236
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"In mesothelioma, ASXL2 enhances BAP1’s tumor-suppressive activity through interactions with BAP1 and UBE2E ."
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