IndraLab

Statements

ASXL2 activates BAP1. 3 / 3
| 3
reach
"BAP1 promotes DEUBAD monoubiquitination resulting in an increased stability of ASXL2, which in turn stimulates BAP1 DUB activity."
30349006
reach
"The DEUBAD domains of ASXL1, ASXL2 and ASXL3 can activate BAP1 by increasing its affinity for ubiquitin."
26739236
reach
"In this paper we describe that similar to the homologous UCH-L5 and RPN13 DEU complex, the DEUBAD domains of ASXL1, ASXL2 and ASXL3 can activate BAP1 by increasing BAP1 's affinity specifically for the ubiquitin in the substrate, through a combination of mild effects."
26739236