IndraLab

Statements

USP22 inhibits sorafenib. 5 / 5
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"USP22 inhibits Sorafenib‐induced ferroptosis through transcriptional suppression of TFRC mediated by deubiquitinating H2BK120ub."
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"It has been reported that depletion of USP22 suppresses angiogenesis in mouse xenograft model of Non-small cell lung cancer [21], and promotes the effect of sorafenib in HCC [22]."
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"39 , 40 It was speculated that TFRC was essential for USP22‐mediated resistance to Sorafenib‐induced ferroptosis."
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"Taken together, our findings demonstrated that USP22 inhibits Sorafenib‐induced ferroptosis through the transcriptional inhibition of TFRC.2.8 USP22 depletion inhibits hepatocellular carcinoma growth and sensitises hepatocellular carcinoma to Sorafenib treatment in mice."
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"We have demonstrated that USP22 depletion inhibits hepatocellular carcinoma cell proliferation and promotes the sensitivity of hepatocellular carcinoma cells to Sorafenib‐induced ferroptosis by in vitro assays."
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